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Minocycline inhibits glial proliferation in the H-Tx rat model of congenital hydrocephalus

James P McAllister and Janet M Miller*

Cerebrospinal Fluid Research 2010, 7:7  doi:10.1186/1743-8454-7-7

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Minocycline in Hydrocephalus

Md.Gulam Mostafa   (2010-05-31 09:59)  Uttara Adhunik Medical College, Bangladesh email

Microglia, a migratory phagocytes remain quiescent in normal brain to provide trophic factors and improve neuronal plasticity. Conditions like ischemia, haemorrhage, hydrocephalus, brain tumor or other CNS trauma might activate neuro-inflammation and consequences are reactive gliosis. A possible therapeutic role of Minocycline, as neuroprotective, anti-inflammatory, neurodegenerative disorders like multiple sclerosis, Amytrophic lateral sclerosis, Huntington’s disease, Parkinson’s disease and in Rheumatoid arthritis have been examining elsewhere. Azithromycin, a newer macrolide of this group has high concentration in phagocytes, azithromycin is actively transported to the site of infection. During active phagocytosis, large concentrations of azithromycin are released. The concentration of azithromycin in the tissues can be over 50 times higher than in plasma. This is due to ion trapping and the high lipid solubility.

The current article is promising and oustanding shwoing the efficacy of minocycline in hydrocephalus. Azithromycin may be a better choice might require investigation, it is a stumulus to investigators to explore the therapeutic dimension of ordinary antibiotics in extraordinary fields.


Dr.Md.Gulam Mostafa, MBBS, Ph.D.
Postdoctoral Fellowship (USA)
Uttra Adhunik Medical, Dhaka, Bangladesh
e-mail: md_gulammostafa@yahoo.com

Competing interests

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