Table 2

CSF concentrations of APP metabolites in two patient groups

Variable

Stroke

median, (SD)

SCI/MCI

median, (SD)

p


CSF sAPP-α ng/mL

499.5 (168.9)

698.0 (248.4)

<0.001


CSF sAPP-β ng/mL

258.0 (74.2)

329.0 (101.4)

<0.005


CSF Aβ X-38 pg/L

1048.0 (576.9)

1141.0 (810.1)

n.s.


CSF Aβ X-40 pg/L

5989.0 (1777.6)

6323.0 (2209.3)

n.s.


CSF AβX-42 pg/L

485.5 (167.5)

483.0 (227.7)

n.s.


Chronic WML cubic mm

5051.8 (11569.0)

971.0 (6105.8)

n.s.


Group differences after age and sex have been corrected for by linear regression. CSF sAPP-α and sAPP-β are significantly lower in the stroke group as compared to the SCI/MCI group. n.s.: not significant.

Selnes et al. Cerebrospinal Fluid Research 2010 7:10   doi:10.1186/1743-8454-7-10

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